Abstract
The utilization of nanomaterials and their compatibility with biological systems have become major concern for the researcher. In this particular study, Fe2O3 nanoparticles (NPs) were synthesized using both green chemistry and chemical-reduction precipitation methods. The biological Fe2O3 NPs were well characterized and found to have a size of 23.01 nm, while the chemical Fe2O3 NPs had a size of 40.80 nm. Stable Fe2O3 NPs were allowed to interact with the serum of cancer patients for different time intervals (24 h, 48 h, and 72 h). The chemical Fe2O3 NPs yielded 41 differentially expressed proteins, whereas the biological Fe2O3 NPs yielded 103. Through proteomics algorithms, a deeper understanding of the obtained proteins revealed the presence of domains and motifs that are primarily associated with the onset of oncogenesis. Notably, key oncogenic and onco-histone protein domains such as PLEC, DEXDc, H2A, and H2B were specifically and uniquely present in the biologically prepared Fe2O3 NP. In conclusion, the efficient use of biological Fe2O3 NPs demonstrated significant potential in adsorbing proteins and peptides, which could be utilized in diagnostic and therapeutic strategies.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
