Abstract
Objective: The main objective of the present study is to correlate the effect of certain enzymes in diagnosis of dengue fever (DF) and impact of these elevated/decreased blood levels of enzymes on patients of DF.
 Methods: The study was carried out on 30 patients suspected to be suffering from DF. Blood sample was collected and tested for various parameters such as protein (albumin), lactate dehydrogenase (LDH), creatinine kinase (CK), C-reactive protein (CRP), acid phosphatase, alkaline phosphatase, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvic transaminase (SGPT).
 Results: Serum enzymes such as LDH and CK were found to be elevated to be a good marker of muscle damage and progression of diseases. CRP as a marker of inflammation was also found to be elevated. Enzymes like acid phosphatase increased abruptly while alkaline phosphatase was irregular. Liver enzymes SGOT and SGPT activity were also enhanced.
 Conclusion: Increased level of transaminases can be reflective of the formation of various amino acids for the synthesis of new protein and for channeling of glutamate and aspartate along with glycine for the synthesis of purine and pyrimidine nucleotides.
 Objective: The main objective of the present study is to correlate the effect of certain enzymes in diagnosis of dengue fever (DF) and impact of these elevated/decreased blood levels of enzymes on patients of DF.
 Methods: The study was carried out on 30 patients suspected to be suffering from DF. Blood sample was collected and tested for various parameters such as protein (albumin), lactate dehydrogenase (LDH), creatinine kinase (CK), C-reactive protein (CRP), acid phosphatase, alkaline phosphatase, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvic transaminase (SGPT).
 Results: Serum enzymes such as LDH and CK were found to be elevated to be a good marker of muscle damage and progression of diseases. CRP as a marker of inflammation was also found to be elevated. Enzymes like acid phosphatase increased abruptly while alkaline phosphatase was irregular. Liver enzymes SGOT and SGPT activity were also enhanced.
 Conclusion: Increased level of transaminases can be reflective of the formation of various amino acids for the synthesis of new protein and for channeling of glutamate and aspartate along with glycine for the synthesis of purine and pyrimidine nucleotides.
Highlights
Dengue virus is a positive-strand RNA virus of Flaviviridae family with four distinct serotypes (DV1-4)
Clinical spectrum illness is produced by the infection of dengue virus that extends to an asymptomatic or mild febrile illness to classic dengue fever (DF) to the most severe dengue commonly referred to as dengue hemorrhagic fever (DHF)
The present research work was carried out on 30 patients who were suspected to be suffering from DF, as they visited at outdoor in the medicine department of Pacific Institute of Medical Sciences (PIMS) Hospital, Umarda, Udaipur
Summary
Dengue virus is a positive-strand RNA virus of Flaviviridae family with four distinct serotypes (DV1-4). It is transmitted to humans by several species of the female Aedes mosquitoes. Dengue virus is a major cause of morbidity throughout the subtropical and tropical regions of the world [1]. Clinical spectrum illness is produced by the infection of dengue virus that extends to an asymptomatic or mild febrile illness to classic dengue fever (DF) to the most severe dengue commonly referred to as dengue hemorrhagic fever (DHF). Studies based on population indicate that asymptomatic infections are mainly the outcomes of dengue virus exposure. The occurrence of DHF is commonly associated with high morbidity and mortality [2]
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