Abstract
Biochemical Studies on Experimental Congenital Malformations: Flavin Nucleotides and Folic Acid in Fetuses and Livers from Normal and Riboflavin-deficient Rats
Highlights
ObjectivesThe purpose of the present study is to test this hypothesis by attempting to establish the critical level of flavin nucleotide concentration
In embryos removed from mothers on Diet 3, the flavin adenine nucleotide (FAD) content is reduced approximately 60% during the critical period of differentiation; it is only 30% below normal in embryos from Diet 2
Pregnant rats were maintained from the first day of gestation on the following diets: Diet 1, adequate in riboflavin; Diet 2, deficient in riboflavin; and Diet 3, a teratogenic diet, deficient in riboflavin, and supplemented with galactoflavin at a level of 60 mg per kg of diet
Summary
The purpose of the present study is to test this hypothesis by attempting to establish the critical level of flavin nucleotide concentration
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