Biochemical Perspectives of Immune Cell Response to Vitamin D

Abstract

Vitamin D use could possibly boost therapeutic response and restrain requirement of antibiotic treatment when used according to recommended dietary allowance (RDA). An increasing role of Vitamin D and its analogues is documented for the controlling of psoriasis, vitiligo, atopic dermatitis, rosacea and acne. Besides this, it also aids in B and T cell activation as well as enhancing the activity of macrophages and monocytes. All these potentially contribute to anti-microbial response of immune system. Evidence supports that vitamin D shows enhanced antimicrobial activity and a deficiency in its RDA dosage may affect general wellbeing and longevity in an irreparable way. Possible mechanism for these effects is by an increased scrutiny of inbound pathogenic microorganisms. Multiple other mechanisms of Vitamin D may decrease the risk of infection. Vitamin D can boost innate immunity by modifying the cytokine response and production of antimicrobial peptides (AMPs). A reduction to infection susceptibility is documented in patients suffering atopic dermatitis. Ability of Vitamin D to balance inflammatory responses and local immunity offers thrilling prospective to understand and better treat chronic inflammatory dermatitis’s. Taking into account the potential antimicrobial benefits and the abundance of broad benefits that an adequate vitamin D level confirms, make it discreet to regularly check vitamin D status and maintain an adequate 25(OH) D levels. Vitamin D establishes itself as an economical prophylactic variant and therapeutic product. It also establishes itself as a synergistic approach to traditional antimicrobial agents. This review outlines the specific responses of immune cells which boosts their antimicrobial responses in combating a wide range of organisms due to vitamin D. These are responses by which vitamin D ensures its therapeutic role in treatment of variety of infections.