Abstract
The Ras superfamily of small G proteins are involved in cell-signaling processes that, ifnot regulated, can lead to disordered cell multiplication, apoptosis inhibition, and tumorigenesis.They function as molecular switches, which through a GTP/GDP exchange cycle, switch on(GTP-bound) or off (GDP-bound) cellular activities. Overexpression of these proteins has beenlinked to many diseases including various cancers. Cdc42, a member of the Rho subfamily ofRas superfamily of small G proteins, participates in the regulation of many cellular processesincluding cell adhesion, mitosis, and cytoskeletal rearrangements.
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