Abstract
Biochemical effects of nandrolone decanoate abuse on experimental animal model
Highlights
Nandrolone decanoate (ND) is one of the most commonly abused anabolic androgenic steroids (AAS) compound in the world due to its androgenic potential associated with the favored anabolic properties [1]
In the present study ingesting male rats with high ND dose (15 mg/kg/week) for either short-term (6 week) or long-term (12 weeks) significantly elevated the level of serum creatinine the recommended ND dose (3mg/kg/week) for short term had no significant effect on serum creatinine
The results revealed that ingesting male rats with the high ND dose (15 mg/kg/week) for either short or long term resulted in significant increases in mitochondrial AST by 49% and 186% respectively as compared to the control
Summary
Nandrolone decanoate (ND) is one of the most commonly abused anabolic androgenic steroids (AAS) compound in the world due to its androgenic potential associated with the favored anabolic properties [1]. The use of ND has been applied for therapeutic purposes and has proven to be effective in reducing loss of body mass and muscle in human immune efficiency virus (HIV) patients [2], increasing the number of satellite cells per muscle fiber [3], and controlling refractory anemia [4]. It is used in the treatment of hypogonadism, bone marrow failure syndromes, bone mineralization and some muscle wasting disorders [5]. The chronic and unregulated use ND results in undesirable outcomes including oxidative stress [8], renal and hepatic injury [9], coronary problems [10] and psychological disorders [11]
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