Abstract
The effect of inhalation of acrolein vapors on the activity of several enzymes of male rat tissues was investigated. Elevated hepatic alkaline phosphatase activity occurred following continous 40-hour exposure to acrolein at concentration as low as 2.1 ppm. Exposure to higher concentrations for shorter periods of time also increased liver AP activity, but the effect was not constant with a constant Ct. Inhalation of ozone, nitrogen dioxide, formaldehyde, and sulfur dioxide also increased liver AP activity. It appears that the hepatic AP response is a nonspecific effect and may be a symptom of the alarm-reaction to stress.
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