Abstract

After 20-minu te exposure to sulfur dioxide of 1, 500 to 2, 000 ppm, amounts of serum chlorine, sodium, potassium and calcium as well as variations of urinary pH in 7 male rabbits were traced for 2 weeks, and the following results were obtained. 1) Serum chlorine amount showed the lowest value 60 minutes after the inhalation of sulfur dioxide, being 86.8% of the preinhalation value, but it returned almost to normal 90 minutes after inhalation. Sodium amount showed the lowest value 30 minutes after the inhalation of sulfur dioxide, being 85.1% of the preinhalation value, but later drew near to the latter and went beyond it after 8 hours. Potassium amount showed a gradual decrease after the inhalation of sulfur dioxide, was lowest at 120th minute, being 78.1% of the preinhalation value. It was restored in some measure thereafter and was slightly up and down around 92% of the preinhalation value after 24 hours. No conspicuous changes were noted in the calcium amount. Urinary pH leaned strikingly toward acidity following the inhalation of sulfur dioxide showing about 5.5 between 1.5 and 24 hours after the inhalation, but it returned to the preinhalation value after 36 hours. 2) It appears that the variation of serum sodium and potassium amounts in the case of acute sulfur dioxide poisoning are of a similar significance as in the poisoning by a low concentration described in Part II, and that the decrease in the chlorine amount is caused by its transference into blood corpuscles from the serum due to changes in the degree of dissociation of hemoglobin. These changes are caused by acidosis due to the presence of a large amount of acidic substances. 3) As regards the excretion of acidic substances produced by the inhalation of sulfur dioxide, it is considered that both NaHSO3 and NaHSO4 are meinly excreted through the urinary route, being replaced later by (NH4)2SO3 and (NH4)2SO4.

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