亜硫酸ガス中毒に関する臨床的ならびに実験的研究 : 第II編 慢性亜硫酸ガス中毒家兎の血清中Cl, Na, K, Caについて

Abstract

With the use of 6 male rabbits weighing from 2, 500 to 3, 000 grams that were subjected daily for 2 hours to an inhalation of sulfur dioxide of 100 ppm a 6-month tracing of variations in the amounts of chlorine, sodium, potassium and calcium in their sera was made and the following results were obtained. 1) Conspicuous changes were observed in the amounts of serum sodium and potassium, while such changes were not noted in the amounts of chlorine and calcium. Sodium displayed a remarkable reduction on the 7th day of the inhalation of sulfur dioxide showing 84.7% of the preinhalation value. Then, an increase was seen with a maximal value on the 21st day, reaching 139.4% of the preinhalation value. Thereafter, comparatively high values were shown until the 90th day with a subsequent decline, though the value was not lower than that of the preinhalation period. Potassium decreased down to 74.7% of the preinhalation value on the 7th day and the value remained between 59.5 and 75.3% of the preinhalation value throughout the subsequent course. 2) Variations in the amounts of chlorine, sodium, potassium, and calcium in the sera of rabbits exposed daily to sulfur dioxide of low concentrations showed almost the same tendency as in the case of refiners in Matsuo Mine described in Part I, bearing probable effects due to variations in adrenal hyperfunction.