Abstract
T here are many paths which lead to the acquisition of clinical knowledge that might profitably be explored, but there is only one h igh road to increase the therapeutic knowledge and that is the controlled clinical tria l . The importance of clinical trial cannot be overlooked. This is the only way to confirm the experimental observations, claims made by previous workers and also to find out additional action and side effect s, which are sometimes observed only in human beings. The drug Parseek Yavani ( Hyocyamus niger ) has been found to have analgesic, antisialagouge and sedative effects. So, the plan to study the trial drug as pre - anesthetic agent with special reference to its bioche mical effect in relation to Ketamine anesthesia was taken up on patients according to American Society of An esthesiologist Grade 1. A ims of present research work wa s t o know the bio - chemical variation in the body after administration of research drug , to s tudy the side effects of drug if any , t o put forward an ideal and safe drug for pre - medication in Sangyaharana (Anesthesia ) and t o establish the efficacy of Ayurvedic drug in the field of pre - medication in Sangyaharana. The r esults of the study shown signi ficant rise of Alkaline Phosphatase value (P < .001 ) before and after premedication in trial group as compared to standard group w hile other biochemical changes were i nsignificant .
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