Abstract
Myocardial infarction (MI) is characterized by an inequity of coronary blood supply and demand, which results inmyocardial ischemic injury and damages the cardiomyocytes. Isoproterenol (ISO) is a synthetic catecholamine causetoxicity leading to severe stress in the myocardium of experimental animals. The aim of the present article is to investigatecardioprotective activity of cranberry extract against ISO-induced cardiotoxicity in adult rats. Oral administration ofcranberry extract at a concentration of 75 and 150 mg/kg b.wt. daily for 28 days showed a significant protection againstinducedalteration in plasma total cholesterol (TC), triacyclglycerols (TG), high density lipoprotein (HDL-C), low densitylipoprotein (LDL-C), tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO) as well as cardiac superoxide dismutase(SOD), glutathione peroxidase (GPx), reduced glutathione (GSH), catalase (CAT) levels. In addition, cranberry extractreduced plasma Creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) aswell as cardiac thiobarbituric acid reactive substances (TBARS) levels (MDA) as compared to control group. Inconclusion, cranberry extract renders resiliency against isoproterenol cardiotoxicity due to its antioxidant and free radicalscavenging activity
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