Abstract
The present study was conducted with objective to study biochemical alterations induced after single intramuscular administration of long acting moxifloxacin at the dose rate of 7.5 mg/kg body weight in six healthy male sheep. After deep intramuscular injection of moxifloxacin, blood samples in collected K3EDTA at 0, 6, 12 hour and 2, 3,4, 5,6,7th day after treatment were analyzed for biochemical Aspartate Aminotransferase (AST) Alanine aminotransferase (ALT), Alkaline Phosphatase (AKP), Acid Phosphatase (ACP), plasma creatinine, plasma Creatine kinase-MB, Blood glucose and Total bilirubin) analysis. The results of the study clearly demonstrated that single intramuscular administration of long acting moxifloxacin in sheep at 7.5 mg/kg body weight did not cause any significant change in values of biochemical parameters in sheep with total absent of clinical signs of adverse reactions or toxicity.
Highlights
The fluoroquinolones are the fastest growing antibacterial class in terms of global revenue, increasingly being used in dairy animals to treat a wide range of infectious diseases [1]
Biochemical alteration as a part of safety profile induced by moxifloxacin needs to be assessed before it is recommended for clinical application in treatment of infections caused by sensitive organism in sheep
The safety study of long acting moxifloxacin in large animal has not been reported but safety profile of other fluoroquinolones like ciprofloxacin, enrofloxacin and levofloxacin was investigated in different species of domestic animal by different research group [4,5,6]
Summary
The fluoroquinolones are the fastest growing antibacterial class in terms of global revenue, increasingly being used in dairy animals to treat a wide range of infectious diseases [1]. Biochemical alteration as a part of safety profile induced by moxifloxacin needs to be assessed before it is recommended for clinical application in treatment of infections caused by sensitive organism in sheep. Present study was planned to investigate the biochemical alteration induced after single intramuscular administration of long acting moxifloxacin in sheep.
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