Bioavailability Study of Sustain Release Preparations of Three Widely used NSAIDS Available in Bangladesh

Abstract

This research has been designed to assess the in vitro bioavailability study of widely distributed and commonly used three analgesic and anti-pyretic drugs namely Diclofenac Sodium, Paracetamol and Ibuprofen sustained release tablets. Three brands of Diclofenac Sodium, four brands of Paracetamol and three brands of Ibuprofen tablets were obtained. Three brands of Diclofenac SR tablets, all brands maintained a steady state release pattern throughout the defined period, i.e. 12 hours. In 1st hour sample D01, D02, D03 were released 43.6%, 36.16%, and 59.85% of drug in dissolution respectively. Four brands of Paracetamol SR tablets, all brands maintained a steady state release pattern throughout the defined period, i.e. 12 hours. In 1st hour sample P01, P02, P03 and P04 were released 78.60%, 89.36%, 74.21%, 78.14 of drug in phosphate buffer (pH 6.8) respectively. Another sustained release tablets was Ibuprofen; all brands maintained a steady state release pattern trough out the defined period, i.e. 12 hours. In 1st hour sample I01, I02, I03 were released 60.46%, 54.02%, 50.57% of drug in phosphate buffer (pH 6.8) respectively. The release rates of the samples were determined for around 12th hours.