Abstract
The plasma and urinary phannacokinetics of controlled release indomethacin microsphere and pellet formulations have been compared after repeated oral administration. Statistical analysis, using the one-tailed independent mean sample t-test, indicated that the microsphere formulation exhibited a trend for greater relative systematic availability (0.25 > P > 0.20) and showed a longer time to reach maximum plasma concentration ( t max) than the pellet formulation ( P < 0.005).
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