Abstract
Two new cyclopeptides simplicilliumtides N and O (1 and 2) along with three known analogues verlamelins A, B and simplicilliumtide J (3-5) were isolated from the deep-sea-derived fungal strain Simplicillium obclavatum EIODSF 020 by bioassay-guided isolation method. Their structures of 1 and 2 were elucidated by spectroscopic analysis, and their amino acid configurations were determined by Marfey’s method. All isolated compounds showed significant antifungal activity against two phytopathogenic fungi Alternaria solani and Colletotricum asianum with MIC values of 0.195–6.250 μg/disc. This study suggests the fungal strain S. obclavatum EIODSF 020 is a new source for developing natural fungicides.
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