Abstract
A composite membrane of the polymer, chitosan, and the silver-exchanged mineral phase, tobermorite, was prepared by solvent casting and characterised by scanning electron microscopy and Fourier transform infrared spectroscopy. The in vitro bioactivity, cytocompatibility and antimicrobial activity of the composite were evaluated with respect to its potential application as a guided tissue regeneration (GTR) membrane. The in vitro bioactivity was verified by the formation of hydroxyapatite on the surface of the membrane in simulated body fluid and its cytocompatibility was established using MG63 human osteosarcoma cells. The presence of silver ions conferred significant antimicrobial activity against S. aureus, P. aeruginosa and E. coli. The findings of this investigation have indicated that the chitosan-silver-tobermorite composite is a prospective candidate for GTR applications.
Highlights
Periodontitis - inflammation and progressive destruction of biodegradable, biocompatible, bioactive, non-antigenic, the tooth attachment apparatus - is one of the most widespread antimicrobial and finds current biomedical application in infectious diseases in the world[1]
The tooth attachment apparatus - is one of the most widespread antimicrobial and finds current biomedical application in infectious diseases in the world[1]. This disease is initiated wound dressings and medical textiles[5,6,7,8,9]. It is a basic linear by the accumulation of bacterial plaque biofilms causing co-polymer of glucosamine and N-acetylglucosamine whose gingivitis, which, if left untreated, leads to the detachment structure resembles that of bone extracellular matrix (ECM) of the epithelial tissue, disconnection of the periodontal . [10,11] In comparison with traditional treatment, the application ligament (PDL) and the loss of cementum and alveolar of bioresorbable chitosan-based guided tissue regeneration (GTR) membranes has been bone[1,2,3]
The powder X-ray diffraction (XRD) pattern of Ag-tobermorite is shown in Figure 1a and closely resembles those of other tobermorites reported in the literature[18,24]
Summary
Periodontitis - inflammation and progressive destruction of biodegradable, biocompatible, bioactive, non-antigenic, the tooth attachment apparatus - is one of the most widespread antimicrobial and finds current biomedical application in infectious diseases in the world[1] This disease is initiated wound dressings and medical textiles[5,6,7,8,9]. It is a basic linear by the accumulation of bacterial plaque biofilms causing co-polymer of glucosamine and N-acetylglucosamine whose gingivitis, which, if left untreated, leads to the detachment structure resembles that of bone extracellular matrix (ECM) of the epithelial tissue, disconnection of the periodontal . The treated periodontal tissues possess Previous studies have indicated that blending chitosan with a long junctional epithelium and are vulnerable to further finely divided bioactive and antibacterial phases, such as bacterial infection and recurrent episodes of periodontitis. bioactive glasses, calcium phosphate minerals and silver
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