Abstract
A new pyrrolidine alkaloid named (Z)-3-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)-1-methylpyrrolidin-2-one was isolated from the ethanol extract of the root barks of Orixa japonica. The structure of the new alkaloid was elucidated on the basis of NMR and MS analysis. The compound exhibited larvicidal activity against the fourth instar larvae of Aedes aegypti (LC50 = 232.09 μg/mL), Anopheles sinensis (LC50 = 49.91 μg/mL), and Culex pipiens pallens (LC50 = 161.10 μg/mL). The new alkaloid also possessed nematicidal activity against Bursaphelenchus xylophilus (LC50 = 391.50 μg/mL) and Meloidogynein congnita (LC50 = 134.51 μg/mL). The results indicate that the crude ethanol extract of O. japonica root barks and its isolated pyrrolidine alkaloid have potential for development into natural larvicides and nematicides.
Highlights
Mosquito-borne diseases affect at least 500 million people around the world [1]
(H→C) correlations correlations of the the pyrrolidine pyrrolidine alkaloid isolated from the ethanol extract of O. japonica root barks
The isolated pyrrolidine alkaloid was tested for its larvicidal activity against the fourth instar larvae of Ae. aegypti, An. sinensis, and C. pipiens pallens
Summary
Mosquito-borne diseases affect at least 500 million people around the world [1]. Dengue fever, mainly transmitted by the yellow fever mosquito (Aedes aegypti L.) and Asian tiger mosquito (Aedes albopictus Skuse), cause 50 million new infections and 24,000 deaths every year [2]. 2016, 21, 1665 nematodes have extensively relied on synthetic fumigant and non-fumigant of plant-parasitic nematicides [6,9]. Plants contain a rich source of bioactive chemicals, since many many plants have been reported to possess larvicidal and nematicidal activities [8,11,12,13,14]. Plants have been reported to possess larvicidal and nematicidal activities [8,11,12,13,14]. To our knowledge, this isTo theour first report of this a pyrrolidine has been isolated has been isolated and identified from japonica.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
