Abstract
Thiazines are a group of heterocyclic organic compounds that are still largely unexplored for their pharmacological activities. There are different available methods for the synthesis of thiazine derivatives in the literature. In this review, we discuss available methods of thiazine preparation through green synthesis methods. Beside their synthesis, many thiazine derivatives are biologically active and play an important role in the treatment of various diseases and show promising results of varying degrees, where they act as antibacterial, antifungal, antitumor, antimalarial, antineoplastic, antiviral, anti-inflammatory, analgesic and anticancer agents and thus they represent an interesting class of heterocyclic medicinal compounds worthy of further exploration.
Highlights
Heterocyclic chemistry research encompasses almost half of the organic chemistry research throughout the world
Heterocyclic thiazine and benzothiazine compounds are a crucial part of medicinal organic chemistry due to their useful medicinal properties
The available data in the literature reveal that thiazines are a considerably vital group of heterocyclic compounds and their applications in the treatment of different infectious and inflammatory diseases are promising
Summary
Heterocyclic chemistry research encompasses almost half of the organic chemistry research throughout the world. It is commonly reported that heterocycles having sulphur or nitrogen atoms or both of them are the general features present in the structures of most of the pharmaceutical and natural compounds [1,2]. They act as multidentate ligands for different metals due to the presence of nitrogen and sulfur atoms and are used extensively in coordination chemistry to obtain new frameworks with potential bioactivity [2].
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