Abstract
Using an ideal biomaterial to treat injured bones can accelerate the healing process and simultaneously exhibit antibacterial properties; thus protecting the patient from bacterial infections. Therefore, the aim of this work was to synthesize composites containing silicate-based bioactive glasses and different types of noble metal structures (i.e., AgI pyramids, AgIAu composites, Au nanocages, Au nanocages with added AgI). Bioactive glass was used as an osteoconductive bone substitute and Ag was used for its antibacterial character, while Au was included to accelerate the formation of new bone. To investigate the synergistic effects in these composites, two syntheses were carried out in two ways: AgIAu composites were added in either one step or AgI pyramids and Au nanocages were added separately. All composites showed good in vitro bioactivity. Transformation of AgI in bioactive glasses into Ag nanoparticles and other silver species resulted in good antibacterial behavior. It was observed that the Ag nanoparticles remained in the Au nanocages, which was also beneficial in terms of antibacterial properties. The presence of Au nanoparticles contributed to the composites achieving high cell viability. The most outstanding result was obtained by the consecutive addition of noble metals into the bioactive glasses, resulting in both a high antibacterial effect and good cell viability.
Highlights
The widespread application of bioactive glasses is not surprising since they are used to treat bone injuries, cancer metastases, and wounds [1]
Cell viability assessment was carried out on a human epidermal keratinocyte cell line (HaCaT, Cell Line Service, Eppelheim, Germany), via the same method that we described in our previous publications [10,27]
Four different composites were prepared to investigate the synergistic effect between bioactive glass composites and two noble metals
Summary
The widespread application of bioactive glasses is not surprising since they are used to treat bone injuries, cancer metastases, and wounds [1]. It is known that additional properties can be conferred to bioactive glasses by adding different metals to them [2,3,4]. The unique properties of gold nanoparticles are related to their (localized) surface plasmon resonance, large surface-to-volume ratio, biocompatibility, low toxicity, and stability [6]. These properties are utilized in several (biomedical) applications [7], such as drug delivery, diagnostics and therapeutics, bionanosensors, and biomedical nanodevices. In vivo assays confirmed the following results: (1) the gold nanoparticles containing bioactive glass embedded in Vaseline ointment showed faster wound regeneration in laboratory rats [11];
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
