Abstract
Thanks to their high biocompatibility and bioactivity, bioactive glasses are very promising materials for soft and hard tissue repair and engineering. Because bioactivity and specific surface area intrinsically linked, the last decade has seen a focus on the development of highly porous and/or nano-sized materials. This review emphasizes the synthesis of bioactive glass nanoparticles and materials design strategies. The first part comprehensively covers mainly soft chemistry processes, which aim to obtain dispersible and monodispersed nanoparticles. The second part discusses the use of bioactive glass nanoparticles for medical applications, highlighting the design of materials. Mesoporous nanoparticles for drug delivery, injectable systems and scaffolds consisting of bioactive glass nanoparticles dispersed in a polymer, implant coatings and particle dispersions will be presented.
Highlights
Since their discovery in the 1970s by Hench, bioactive glasses have been the subject of intensive investigations as biomaterials for bone tissue repair and replacement [1]
With a high surface-to-volume ratio, bioactive glass nanoparticles (20–500 nm) are of tremendous interest because they present a larger specific surface area, and a higher surface energy compared to micrometric-sized particles [5,6]
The first part of this review focused on the preparation of bioactive glass nanoparticles through soft chemistry processes
Summary
Since their discovery in the 1970s by Hench, bioactive glasses have been the subject of intensive investigations as biomaterials for bone tissue repair and replacement [1] Their attractiveness lies in their ability to chemically bond with host tissues that are directly related to their atomic structure. With a high surface-to-volume ratio, bioactive glass nanoparticles (20–500 nm) are of tremendous interest because they present a larger specific surface area, and a higher surface energy compared to micrometric-sized particles [5,6]. Their nanometric size allows material shaping versatility. The focus will always be placed on the design of the bioactive materials, and on their structure/properties relationships
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