Abstract
Bioactive glass (BG) was made by the sol–gel method and doped with boron (B) to increase its bioactivity. Microstructures of BG and B-doped BG were observed by scanning electron microscopy, and phase identification was performed using an X-ray diffraction diffractometer. The ion concentrations released after soaking in simulated body fluid (SBF) for 1, 4, and 7 days were measured by inductively coupled plasma mass spectrometry, and the pH value of the SBF was measured after soaking samples to determine the variation in the environment. Brunauer–Emmett–Teller (BET) analysis was performed to further verify the characteristics of mesoporous structures. High performance liquid chromatography was used to evaluate the drug delivery ability of teicoplanin. Results demonstrated that B-doped BG performed significantly better than BG in parameters assessed by the BET analysis. B-doped BG has nanopores and more rough structures, which is advantageous for drug delivery as there are more porous structures available for drug adsorption. Moreover, B-doped BG was shown to be effective for keeping pH values stable and releasing B ions during soaking in SBF. The cumulative release of teicoplanin from BG and B-doped BG reached 20.09% and 3.17% on the first day, respectively. The drug release gradually slowed, reaching 29.43% and 4.83% after 7 days, respectively. The results demonstrate that the proposed bioactive glass has potential as a drug delivery system.
Highlights
Bioactive ceramics are mainly composed of calcium, phosphate, silica, and oxygen
Calcium nitrate was used as the calcium source, and the nitrate was removed to form the mesoporous structure
The nanoscaled pores are distributed on the surface, and more rough structures are shown in BG_B100
Summary
Bioactive ceramics are mainly composed of calcium, phosphate, silica, and oxygen. Regarding clinical use, they can chemically bond with surrounding soft tissue and hard tissue, such as bone.This type of inorganic material is widely employed in orthopedic and dental settings [1]. Bioactive ceramics are mainly composed of calcium, phosphate, silica, and oxygen. Regarding clinical use, they can chemically bond with surrounding soft tissue and hard tissue, such as bone. They can chemically bond with surrounding soft tissue and hard tissue, such as bone This type of inorganic material is widely employed in orthopedic and dental settings [1]. Boron (B) can influence bone growth and can act as a nutrition component to enhance bone strength under compression [4]. It improves bone health, stimulates wound healing, and has been demonstrated to increase bioactivity
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