Abstract
Four new compounds, including three drimane sesquiterpenoids purpurides E–G (1–3) and one isocoumarin peniisocoumarin H (4), together with 15 known compounds, were isolated from the marine-sourced fungus Penicillium minioluteum ZZ1657. Their structures were elucidated by a combination of the HRESIMS data, extensive NMR spectroscopic analyses, and single crystal X-ray diffractions. Purpurides E (1) and F (2) are two N-acetyl-l-valine-conjugated drimane sesquiterpenoids and showed antimicrobial activities against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with MIC values of 6–12 and 3–6 μg/mL, respectively. Purpuride G (3) showed antiproliferative activities against human glioma U251 and U87MG cells with IC50 values of 4.49 and 10.9 μM, respectively.
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