Bioactive assessment of bioactive glass nanostructures synthesized using synthetic and natural silica resources

Abstract

AbstractThe sol‐gel route of synthesizing bioactive glasses of composition 45S5 has shown higher compatibility than the melt casting method. In bioactive glass synthesis, a major silica source is derived from the synthetic tetraethyl orthosilicate precursor. This work demonstrates the sol–gel‐derived bioactive glass prepared from rice husk and TEOS as silica sources. In this study, the effect of crystallization with respect to the silica source in bioactive glass composition was investigated to gain further understanding on the processes involved in the fabrication of bioglass. The in vitro biodegradation and apatite formation of the bioactive glass in simulated body fluid was investigated by spectroscopic and morphological studies. Both the bioactive glasses show a change in morphology toward nanostructured apatite formation after in vitro immersion studies. Further, the hemocompatibility of bioactive glass prepared using rice husk is similar to bioactive glass prepared from organic silica sources. This promises the possibility of synthesizing low cost and biocompatible bioactive glass 45S5 system for tissue engineering applications.