Abstract
Despite the advances that have been achieved in developing wound dressings to date, wound healing still remains a challenge in the healthcare system. None of the wound dressings currently used clinically can mimic all the properties of normal and healthy skin. Electrospinning has gained remarkable attention in wound healing applications because of its excellent ability to form nanostructures similar to natural extracellular matrix (ECM). Electrospun dressing accelerates the wound healing process by transferring drugs or active agents to the wound site sooner. This review provides a concise overview of the recent developments in bioactive electrospun dressings, which are effective in treating acute and chronic wounds and can successfully heal the wound. We also discuss bioactive agents used to incorporate electrospun wound dressings to improve their therapeutic potential in wound healing. In addition, here we present commercial dressings loaded with bioactive agents with a comparison between their features and capabilities. Furthermore, we discuss challenges and promises and offer suggestions for future research on bioactive agent-loaded nanofiber membranes to guide future researchers in designing more effective dressing for wound healing and skin regeneration.
Highlights
Skin plays an essential role in protecting our body against any physical and chemical injury and water loss, and contributes to the maintenance of bodily homeostasis [1,2,3]
For the first time, a hybrid nanofiber membrane was proposed as a bioactive wound dressing by Homaygohar et al The results of this study showed that biohybrid nanofibers have elastic modulus and elongation (300% and 58%, respectively) comparable to regular poly(ε-caprolactone) (PCL) nanofibers
Significant progress has been demonstrated in the development of novel and effective solutions for skin tissue engineering
Summary
Skin plays an essential role in protecting our body against any physical and chemical injury and water loss, and contributes to the maintenance of bodily homeostasis [1,2,3]. The dermis, the inner layer of skin, is full of extracellular matrix (ECM), mechanoreceptors, and vasculature, and this layer can provide the skin with immunity, nutrients, and mechanical strength [6,7]. Membranes 2021, 11, x Membranes 2021, 11, 702 extracellular matrix (ECM), mechanoreceptors, and vasculature, and this layer can provide the skin with immunity, nutrients, and mechanical strength [6,7]. The electrospinning technique allows the production of a suitable nanofibrous membrane to deliver bioactive agents or. The electrospinning technique allows the production of a suitable nanofibrous membrane to deliver bioactive agents or phpahramrmacaocloogloicgaicl aalgaegnetsnttsotothtehdeadmamagaegdedsitseitoefosfksiknintotoacaccecleelreartaetethtehesksikninrergeegneenreartaiotinon prporcoecsess[s1[41,249,2]9. Adddidtiiotinoanllayl,lyn,enwewbiobliogloicgailclayllayctaicvteivaegaegnetsntussuedseidnicnocmobmin- abintiaotniownitwhiethlecetlreocstprousnpuwnouwnodudnrdesdsirnegsssintogsimtopriomvpertohveeir theeirraptheeurtaicpepuottiecntpioalteintwiaol uinnd wohueanldingheaarleiningvaesretigiantveeds.tiIgnaateddd.itIinona, dhderiteiowne, phreerseenwt ecopmremsenrctiaclodmremsseirncgiasllodardesesdinwgisth loabdioeadctwiviethagbeionatsctwiviethagaecnotms pwairthisoancboemtwpaereinsotnhebiertfweaeteunretsheainrdfecaatpuarbesiliatineds.cFaupratbhielirtmieos.re, Fuwrtehderismcuosrse,chwaellednisgceussasncdhpalrloemngiseessaanndd pofrfoemr sisuegsgeasntdionosfffeorrsfuugtugreestrieosnesarfcohr ofnutbuiroeacrtei-ve seagrcehnto-lnoabdioeadctniavneoafigbeenrt-mloeamdbedranaens otofibgeuridmeefmutburraenreesetaorgchueidrseifnudtuerseigrneisnegarmchoerreseifnfedctei-ve sigdnreinsgsinmgofroerewffoecutnivdehderaelsinsignganfdorswkionurnegdehneearlaitnigona.nd skin regeneration
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