Abstract
β-carotene (βC) is an essential nutrient for health. It is a potent antioxidant, anti-cancer, and anti-inflammatory substance. However, βC has high hydrophobicity property, indicating a low absorption level in the digestive tract. The bioavailability of βC is reasonably low. Lipid-based delivery systems such as nanostructured lipid carriers (NLC) potentially can help to overcome this problem. This research evaluated the bioaccessibility of the nanostructured mixture of palm stearin (PS) and palm olein (PO) and the antioxidant activity of βC in the structure. β-carotene bioaccessibility was studied by measuring the micellization during in vitro digestion. Antioxidants activity was measured by 2.2′-azino-bis (3-ethylbenzothiazoline- 6-sulphonic acid) (ABTS) and 2, 2 – diphenyl -1- picrylhydrazyl (DPPH) reduction methods. In vitro gastrointestinal digestion model indicated that nanostructured lipid carrier enhanced bioaccessibility and antioxidants activity of βC. This suggests that the formulated NLC system can be used effectively to deliver lipophilic bioactive such as βC in beverage products.
Highlights
Lipid-based systems are one of the common methods for carrying nonpolar bioactive with the aim of increasing the solubility of these components
Lipid-based delivery system is capable of increasing bioaccessibility and antioxidant activity of lipophilic bioactive substances by using various types of lipids such as Medium Chain Triglycerides (MCT), oleic acid, glyceryl behenate, glyceryl palmitostearate, glyceryl monostearate/monostearate, cetyl palmitate, stearic acid, wax and other types of lipids (Tamjidi et al, 2013)
This study showed that βC can be loaded effectively within nanostructured lipid carriers (NLC) from a mixture of palm stearin and palm olein
Summary
Lipid-based systems are one of the common methods for carrying nonpolar bioactive with the aim of increasing the solubility of these components. A lipid-based delivery method can circumvent these β-carotene constraints (Pan et al, 2016). The delivery system is expected to increase the solubility and stability of the bioactive substances. These bioactive substances can be more absorbed in the digestive system, as indicated by their increased bioaccessibility. The simulated gastrointestinal tract model is widely used as a simplified method to determine the release performance of NLC delivery system (Gonçalves et al, 2021; Dima et al, 2020; Park et al, 2018; Qian et al, 2012). Static condition in a controlled environment is preferable to provide valuable preliminary and complementary data to in vitro models (Goncalves et al, 2021; Martínez-Ballesta et al, 2018)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
