Abstract
Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ∼10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.
Highlights
Advances in photonics have stimulated significant progress in medicine, with many techniques in routine clinical use
We investigated the optical and mechanical properties of various polymers in an H-shaped waveguide over 24 h when immersed into phosphatebuffered solution (PBS) (Fig. 3a)
To date, biocompatible and biodegradable polymers have been extensively studied and used in many fields of medicine such as cardiovascular medicine[34], orthopedics[35] and neurology[36]. They show minimal systemic toxicity and the rate of resorption of polymeric implants can be tailored to minimize the probability of tissue irritation during degradation
Summary
Advances in photonics have stimulated significant progress in medicine, with many techniques in routine clinical use. Light-guiding hydrogel waveguides have been developed for sensing and therapies[24,25,26,27,28] Synthetic polymers, such as poly (D,L-lactide-co-glycolide) (PLGA) and poly(L-lactic acid) (PLA), are widely used for conventional implantable devices and injectable products, for example, for resorbable sutures, but have not been explored for optical applications. We demonstrate an application to photochemical tissue bonding, for which a thin flexible waveguide comb is inserted into a skin incision model to deliver light uniformly along the full thickness (410 mm) of the skin tissue This allows watertight crosslinking between the tissues to be formed in situ; the waveguide need not be removed from the site after the procedure, as it is eventually biodegraded and absorbed by the tissue. This paradigm-shifting approach is expected to impact a variety of applications in the field of photomedicine, such as health monitoring, controlled drug release and chronic photodynamic therapy
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
