Abstract
The solubility of carbonated hydroxyapatite powders and granulated carbonated hydroxyapatite produced from the synovial biofluid model solution has been studied. The kinetic characteristics of dissolution were determined. It was found that the solubility of carbonated hydroxyapatite is higher as compared to that of hydroxyapatite. The impact of the organic matrix on the rate of sample dissolution was revealed. For HA-gelatin composites, as the gelatin concentration grows, the dissolution rate becomes greater, and a sample of 6.0 g / L concentration has higher resorbability. The results of the research can be used to study the kinetics of dissolution and the biocompatibility of ceramic materials for medicine, namely for reconstructive surgery, dentistry, and development of drug delivery systems.
Highlights
Much attention is paid to studying and improving the bioactive properties of the materials produced based on calcium phosphates
A significant disadvantage of the HA-based material most frequently used for implantation is its low bioresorbability rate. This problem can be solved through chemical modification of calcium phosphate, since it is known that isomorphic impurities introduced into calcium phosphate may increase both its bioactive properties and solubility
To make granules of carbonated hydroxyapatite (CHA) the resulting powder with a weight of 0.2–1 g was mixed with 1.5–7.5 ml of the 5, 10 and 15 mass. % aqueous gelatin solution and stirred to obtain a homogeneous mass
Summary
Much attention is paid to studying and improving the bioactive properties of the materials produced based on calcium phosphates. Interest in these compounds is due to the fact that the human bone tissue is a biocomposite based on hydroxyapatite (HA) with an admixture of amorphous calcium phosphates, brushite, octacalcium phosphate [1,2] and high-protein collagen. A significant disadvantage of the HA-based material most frequently used for implantation is its low bioresorbability rate This problem can be solved through chemical modification of calcium phosphate, since it is known that isomorphic impurities introduced into calcium phosphate may increase both its bioactive properties and solubility
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