Abstract

The calix[4]arenes functionalized at the macrocyclic upper rim with α-hydroxyphosphonic, α-aminophosphonic or methylnebisphosphonic acid groups were synthesized. The complexes formed between the bio-relevent calix[4]arene derivatives and amino acids or dipeptides as well as inhibition effects of calix[4]arene phosphonic acids on alkyline phosphatases acitiy were studied.

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