Abstract
A complex based on 5,11,17,23-tetra-t-butyl-25,27-bis(carboxymethoxy)-26,28-dihydroxycalix[4]arene and a-aminobutyric acid was synthesized. Complexation between the macromolecule and amino acid was confirmed using IR, UV, and PMR spectroscopy, mass spectrometry, and fluorimetry. UV spectrophotometric titration showed that the calix[4]arene derivative could form complexes of stoichiometry 1:1 and 2:1 (host:guest). The synthesized complex exhibited prolonged anticonvulsant activity, which was evaluated by determining the minimum effective doses of corazole inducing clonic-tonic convulsions and tonic extension.
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