Abstract
Multitudinous industrial products in daily life put human health at risk of heavy metal exposure, and natural bacteria have displayed superior performance in bioadsorption and biodegradation of heavy metal. In this study, a bacteria‐based bioreactor is developed to precisely bioadsorb lead (Pb) ions, eliminate concomitant reactive oxygen species (ROS), and remit the injury of acute/chronic Pb poisoning. A nonpathogenic bacteria Escherichia coli MG1655 (Bac) is decorated with antioxidative cerium oxide nanoparticles (Ceria) on the surface through a bio‐orthogonal reaction, and the complex bioreactor could spontaneously aggregate in organs with high concentration of Pb. Furthermore, the excess Pb is bioadsorbed by bacteria and the concomitant ROS is eliminated by Ceria nanoparticles. In vitro and in vivo studies demonstrate that this integral biotic/abiotic hybrid bioreactor successfully realizes detoxication of Pb and reparation of injury, also accompanied with inappreciable side effects.
Highlights
Multitudinous industrial products in daily life put human health at risk is generally treated with medication (2, 3-dimercaptosuccinic acid, DMSA or of heavy metal exposure, and natural bacteria have displayed superior edetate calcium disodium, EDTA)[11] and performance in bioadsorption and biodegradation of heavy metal
The excess precisely bioadsorb lead (Pb) is bioadsorbed by bacteria and the concomitant reactive oxygen species (ROS) is eliminated by cerium oxide nanoparticles (Ceria) nanoparticles
Many nonpathogenic bacteria with functions of essential cations[1] to exert severe toxicities in or probiotics have been widely modified by nanotechnology[21]
Summary
Multitudinous industrial products in daily life put human health at risk is generally treated with medication (2, 3-dimercaptosuccinic acid, DMSA or of heavy metal exposure, and natural bacteria have displayed superior edetate calcium disodium, EDTA)[11] and performance in bioadsorption and biodegradation of heavy metal. Escherichia coli MG1655 (Bac) is decorated with antioxidative cerium oxide for chronic lead poisoning in lead exposure nanoparticles (Ceria) on the surface through a bio-orthogonal reaction, and districts.[11,12,13] it is quite necthe complex bioreactor could spontaneously aggregate in organs with high concentration of Pb. the excess Pb is bioadsorbed by bacteria and the concomitant ROS is eliminated by Ceria nanoparticles.
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