Abstract
Early planning of problem circumvention in scale-up (or scale-down) by in silico and real-lab comparison exercises should supersede approaches to separation procedures intended to deliver green-technology outcomes. Downstream processing (DP) applied to cleaner technology should be afforded equal status with other essential stages in designer unit operation process components. This necessitates a ‘whole-process’ reappraisal so that noxious side products are avoided in the process and in DP. Elimination of dangerous reactive oxygen species is essential for a greener DP outcome.
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