Abstract
For the first time, an aqueous extract of Melilotus officinalis was used to synthesize bimetallic silver selenide chalcogenide nanostructures (Ag2Se-NCs). The formation of NCs was confirmed and characterized by UV–visible and FTIR spectroscopy, SEM and TEM imaging, XRD and EDX crystallography, zeta potential (ZP) and size distribution (DLS). The bioactivities of biosynthesized Ag2Se-NCs, such as antibacterial, antibiofilm, antioxidant and cytotoxicity potentials, were then examined. Bio-based Ag2Se-NCs were successfully synthesized with mostly spherical shape in the size range of 20–40 nm. Additionally, the MIC and MBC values of Ag2Se-NCs against β-lactam-resistant Pseudomonas aeruginosa (ATCC 27853) were 3.12 and 50 µg/ml, respectively. The DPPH scavenging potential of Ag2Se-NCs in terms of IC50 was estimated to be 58.52. Green-synthesized Ag2Se-NCs have been shown to have promising benefits and could be used for biomedical applications. Although the findings indicate promising bioactivity of Ag2Se-NCs synthesized by M. officinalis extract (MO), more studies are required to clarify the comprehensive mechanistic biological activities.
Highlights
Silver chalcogenides, A g2Se, are semiconductors with impressive physicochemical properties being used in electronics, optical conductors, infrared detectors, electromagnetic field sensors and optical filters
Phytochemical analysis of M. officinalis extract (MO) extract Phytochemical compounds in MO extract were quantitatively identified using standard methods based on colorimetric observations
Many studies have previously demonstrated that M. officinalis contains major biologically active metabolites such as flavonoids, coumarins, steroid glycosides, saponins and other compounds (Liu et al 2018)
Summary
A g2Se, are semiconductors with impressive physicochemical properties being used in electronics, optical conductors, infrared detectors, electromagnetic field sensors and optical filters. A variety of studies have examined the different properties of Ag2Se on the scale of microstructures, nanostructures, quantum dots and bulk forms (Martinez-Nuñez et al 2016; Vo et al 2016). Ag2Se nanostructures, in particular quantum dots, have unique properties that make them suitable for bioimaging (Yang et al 2018). Ag2Se-NCs can be synthesized in two distinct crystalline phases. The most common processes, including high-temperature synthesis, microwave irradiation, electrochemical method and sonochemical reaction, have been developed for the synthesis of Ag2Se-NCs (Jafari et al 2013). These techniques have limitations due to the use of chemical reagents, various solvents and increased energy consumption. Many researchers have attempted alternative and more accessible approaches to achieve Ag2Se nano-chalcogenides (Ayele 2016; Gholami et al 2018; Sibiya and Moloto 2017; Yang et al 2018)
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