Abstract
Modern breakthroughs in the fields of proteomics and DNA micro-arrays have widened the horizons of nanotechnology for applications with peptides and nucleic acids. Hence, biomimetic interest in the study and formulation of nanoscaled bio-structures, -materials, -devices and -therapeutic agent delivery vehicles has been recently increasing. Many of the currently–investigated functionalized bio-nanosystems draw their inspiration from naturally-occurring phenomenon, prompting the integration of molecular signals and mimicking natural processes, at the cell, tissue and organ levels. Technologically, the ability to obtain spherical nanostructures exhibiting combinations of several properties that neither individual material possesses on its own renders colloidal core-shell architectured nanosystems particularly attractive. The three main developments presently foreseen in the nanomedicine sub-arena of nanobiotechnology are: sensorization (biosensors/ biodetection), diagnosis (biomarkers/bioimaging) and drug, protein or gene delivery (systemic vs. localized/targeted controlled–release systems). Advances in bio-applications such as cell-labelling/cell membrane modelling, agent delivery and targeting, tissue engineering, organ regeneration, nanoncology and immunoassay strategies, along the major limitations and potential future and advances are highlighted in this review. Herein, is an attempt to address some of the most recent works focusing on bio-inspired and -functional polymeric-based core-shell nanoparticulate systems aimed for agent delivery. It is founded, mostly, on specialized research and review articles that have emerged during the last ten years.
Highlights
The interplay between nanoscience and nanomedicine continues to be the hallmark of current scientific research worldwide, promising to change every aspect of human life via creating revolutionary materials of biological origin for use in the diagnosis and treatment of devastating human diseases [1,2]
Out of the superfluity of size-dependant properties in the presently-available nanosystems, optical [6] and magnetic [7] effects continue to be the most used for biological applications with significant advancement reported in the fields of drug delivery, gene therapy, novel drug synthesis, bioimaging and detection of cancerous cells [1,2,3,6,7]
Recent progress, especially in core-shell architectured polyelectrolytes- or polysaccharides-incorporated nanostructures, their bio-compatibilization, responsiveness and multi-functionality; make themsmart‘ orintelligent‘ and promising in diagnostic medicine, localized, targeted and predictable delivery of active therapeutic agents, soft/hard tissue engineering and organ regeneration [8,9,10]. In this review, such developmental advances limited to the development of bio-inspired and bio-functional, polymeric-based, core-shell nanosized systems applied in tackling diverse biomedical problems are presented concisely with a selective focus on the reported simplicity of design, formulation, variation/tailoring, administration, evaluation and translation
Summary
The interplay between nanoscience and nanomedicine continues to be the hallmark of current scientific research worldwide, promising to change every aspect of human life via creating revolutionary materials of biological origin for use in the diagnosis and treatment of devastating human diseases [1,2]. Recent progress, especially in core-shell architectured polyelectrolytes- or polysaccharides-incorporated nanostructures, their bio-compatibilization, responsiveness and multi-functionality; make themsmart‘ orintelligent‘ and promising in diagnostic medicine, localized, targeted and predictable delivery of active therapeutic agents, soft/hard tissue engineering and organ regeneration [8,9,10]. In this review, such developmental advances limited to the development of bio-inspired and bio-functional, polymeric-based, core-shell nanosized (mainly, colloidal) systems applied in tackling diverse biomedical problems are presented concisely with a selective focus on the reported simplicity of design, formulation, variation/tailoring, administration, evaluation and translation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
