Abstract
The binding of levonorgestrel and norethisterone in plasma from various species was compared to that in the human. In the human, baboon and rhesus monkey, binding of norgestrel and norethisterone occurred mainly to sex hormone binding globulin, which had a greater affinity for norgestrel than for norethisterone, and to a much less extent to albumin. Although some binding of the gestagens occurred to SHBG in the dog and rabbit, this was much less than in the primates and more binding occurred to albumin. In the guinea-pig and rat, binding occurred only to albumin. Based on these studies the baboon and rhesus monkey, but not the other species, might be appropriate animal models for contraceptive studies in humans.
Published Version
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