Abstract
The reactions between [Pt(terpy)Cl+ and thiols, such as glutathione, L-cysteine, D-penicillamine and thioglycolic acid have been Studied by conventional UV-VIS spectrophotometry and H NMR spectroscopy. The second-ordero rate constants, K2, are similar for these four thiols, varying between 1.06 x 10-2 and 6.10 x 10+3 M-1 s-1 at 25°C. The activation entropies have large negative values between -100 and -200 J mol-1 which are compatible with an associative A mechanism. However, L-methionine, as thioether ligand, is unreactive under the same experimental conditions. The obtained results have been analyzed in relation to the antitumor activity and toxicity of platinum(II) complexes.
Highlights
The study of the aqueous chemistry of platinum(II) complexes has been extensively investigated over the past few decades especially due to its relevance to anticancer activity[I-3]
Since interactions between platinum(II) complexes and sulfur-containing ligands are very important from biological and medicinal aspects, in the present paper, we reported a study of the rection between [Pt(terpy)Cl] and some biologically important thiols such as" glutathione, L-cysteine, D-penicillamine and thioglycolic acid
Glut athi one Complex formation between [Pt(terpy)Cl] and those thiols have been studied as a function of temperature (288 308 K) by the use of conventional UV-VIS spectrophotometry and H NMR spectroscopy
Summary
The study of the aqueous chemistry of platinum(II) complexes has been extensively investigated over the past few decades especially due to its relevance to anticancer activity[I-3]. Since interactions between platinum(II) complexes and sulfur-containing ligands are very important from biological and medicinal aspects, in the present paper, we reported a study of the rection between [Pt(terpy)Cl] and some biologically important thiols such as" glutathione, L-cysteine, D-penicillamine and thioglycolic acid. Glut athi one Complex formation between [Pt(terpy)Cl] and those thiols have been studied as a function of temperature (288 308 K) by the use of conventional UV-VIS spectrophotometry and H NMR spectroscopy.
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