Abstract
In an attempt to determine the role of inert and labile groups in the antitumour activity and toxicity of platinum — amine complexes, J. P. Macquet observed that modifications in the inert groups may modulate the activity against tumour cells, whereas changes in the leaving groups may affect the “in vivo” toxicity (1). In the last few years we carried out a systematic study on the synthesis of pure samples of neutral and ionic platinum complexes with straight chain amines in order to appreciate the cytostatic activity changes with the chain length increase. In previous papers we reported the synthesis and characterization of the complexes having generalformulae cis- and trans-|PtL2X2|, |PtL3X|X and |PtL4|X2, where X = halide and L = propan-1-amine (Pra) and hexan-1-amine (Hea) (2–5).
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