Binaural interactions of electrically and acoustically evoked responses recorded from the inferior colliculus of guinea pigs

Abstract

Binaural interactions within the inferior colliculus (IC) elicited by electric and acoustic stimuli were investigated in this study. Using a guinea pig model, binaural acoustic stimuli were presented with different time delays, as were combinations of binaural electric and acoustic stimuli. Averaged evoked potentials were measured using electrodes inserted into the central nucleus of the IC to obtain the binaural interaction component (BIC), computed by subtracting the sum of the two monaural responses from the binaural response. The BICs to acoustic-acoustic stimulation and electric-acoustic stimulation were found to be similar. The BIC amplitude increased with stimulus intensity, but the shapes of the delay functions were similar across the levels tested. The gross-potential data are thus consistent with the thesis that the central auditory system processes binaural electric and acoustic stimuli in a similar manner. These results suggest that the binaural auditory system can process combinations of electric and acoustic stimulation presented across ears and that evoked gross potentials may be used to measure such interaction.