Abstract
This is a concise seminar account of the current knowledge and concepts of the metabolism of pigments involved in the production of jaundice. The chemistry of the conjugation of bilirubin with glucuronic acid compounds, which explains the nature of the pigments that give the direct and indirect van den Bergh reactions is described. The biosynthesis and physiology of the bilirubin glucuronides as they relate to clinical manifestations in jaundice are outlined. Particular attention is given to the various types of jaundice occurring in the newborn infant. In many jaundiced infants the capacity of the liver to conjugate bilirubin is reduced to 1 to 2% of that in adults.
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