Abstract
Abstract Nephritic, hepatic and immune failures would lead to the overload of endogenous toxic molecules (e.g. bilirubin, cholic acid, uric acid, creatinine etc.) in human bodies. It is fatal in most cases and extracorporeal blood purification (ECBP) is powerful first-aid therapy. Adsorbents are key parts of ECBP apparatus. Mesoporous silicas should be promising candidates for these medical adsorbents, but there is no report about this. Herein, pure and amine-grafted mesoporous silicas have been applied to adsorb bilirubin, cholic acid, uric acid, creatinine and phenobarbital for the first time. These mesoporous materials show high adsorption capacities for bilirubin and uric acid in phosphate buffer solution (PBS). Effects of pore sizes, amine-modification, temperature and ionic strength on their bilirubin adsorption capacities have been studied in detail.
Highlights
There are exogenous and endogenous poisons overloading in human body [1]
Hepatic and immune failures lead to overload of endogenous toxic molecules and pull patients to death's door
Pure silica MCM-41 samples were prepared by the hydrolysis of cetyl-trimethyamonium bromide (CTAB) and TEOS in basic solution according to the published procedure
Summary
There are exogenous and endogenous poisons overloading in human body [1]. Acute medicament (e.g. soporific) toxicosis is the most common exogenous case. Pure and amine-grafted mesoporous silicas have been prepared and applied to adsorb bilirubin, cholic acid, uric acid, creatinine, etc. Amine-grafting, temperature and ionic strength on the bilirubin adsorption capacities of these materials have been studied in detail.
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