Abstract
Bile acid kinetics, steroid balance and biliary lipid composition were studied in 8 patients with hyperlipoproteinaemia (HLP) type III (broad-beta-disease). As a general finding the formation of bile acids exceeded the range encountered in normolipidaemic subjects, but the mean net steroid balance remained normal. On the basis of previous findings of a close correlation between the synthesis of VLDL-triglycerides and bile acids in other types of HLP it is suggested that HLP type III may be associated with an enhanced VLDL production. As a further indication of a disturbed cholesterol metabolism the bile was supersaturated with cholesterol in all subjects.
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