Abstract
Chlorpromazine (CPZ) and trifluoperazine (TFP) are amphipathic antipsychotic drugs with a range of putative membrane protein targets, as well as off-target effects that underlie their complex pharmacological profiles. We have shown that antipsychotics alter lipid bilayer properties, as reported by the bilayer-spanning gramicidin channels, which raises the possibility that CPZ and TFP may exert, at least part of their action by altering lipid bilayer properties. Here we explore the role of charge on CPZ’s and TFP’s bilayer-modifying potency following Malheiros et al.
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