Abstract
Iron wires (0.3 mm in diameter and 1.2 mm in length) were lodged in the left eyes of albino mice. 4 weeks after the experiment, the left and right eyes were sectioned and observed by light microscopy for any histopathology. Immunohistochemical techniques were also employed to identify macrophages and T cells. In the first case, both left (wire-lodged) and right eyes of experimental animals demonstrated pathological changes. The left eyes showed degeneration of photoreceptors and infiltration of lymphocytes at the vicinity of the pigment epithelium. The right eyes also showed degeneration of the pigment epithelium with infiltration of macrophages and lymphocytes around these areas. Immunohistochemistry revealed the presence of macrophages (44%), helper/inducer T cells (37%) and cytotoxic/suppressor T cells (19%) in the pigment epithelia and retinae of both eyes. Our results indicate that, following traumatic injury of one eye, not only the lesioned eye undergoes degeneration, but the other nonlesioned eye is affected as well, and immunologic cells are involved.
Published Version
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