Abstract
A single tube-feeding of l-tryptophan to well-fed adrenalectomized rats resulted in a marked enhancement in [ 3H]leucine incorporation into intracellular hepatic ferritin, and plasma albumin, transferrin and fibrinogen in vivo, compared to both water-fed adrenalectomized and sham-operated controls. The in vivo incorporation of [ 3H]leucine into total liver, brain, and kidney proteins in well-fed adrenalectomized rats was also considerably stimulated by tryptophan. When the adrenalectomized rats were pretreated with actinomycin-D, a further administration of tryptophan caused only a 15–30% increment in [ 3H]leucine incorporation into ferritin, albumin, transferrin, and fibrinogen, whereas in the absence of the antibiotic, tryptophan resulted in a 45–70% increment of the same, compared to water-fed controls. In well-fed adrenalectomized rats, a single tube-feeding of tryptophan also caused a minor 11% enhancement in [ 14C]orotic acid incorporation into mixed hepatic RNA as compared to water-fed controls.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call