Abstract

Periodic stimulation of an aggregate of spontaneously beating cultured cardiac cells displays phase locking, period-doubling bifurcations and aperiodic “chaotic” dynamics at different values of the stimulation parameters. This behavior is analyzed by considering an experimentally determined one-dimensional Poincaré or first return map. A simplified version of the experimentally determined Poincaré map is proposed, and several features of the bifurcations of this map are described.

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