BIFLUOROPHORES BASED ON NAPHTHALIC ACID DERIVATIVES AS BIOLOGICALLY ACTIVE SUBSTANCES

Abstract

A large number of organic compounds, capable to luminesce under influence of various types of radiation, are known nowadays. These substances are called luminophores. Features of the chemical structure of these compounds determine their luminescent properties and behavior of a specific luminophore molecules in one or another environment. Possessing a number of spectral properties, luminophores are widely used in many spheres of human a ctivity. Their usage in biology and medicine plays an important role. Number of new methods of biological research, developed on the basis of luminescent dyes, is growing very quickly. This explains the need for synthesis of new luminescent dyes. Bright and water-soluble fluorescent dyes, for example, are important for sensitive detection of DNA via fluorescent probes. Currently, search for new potential antiviral agents is divided in two main strategies. One trend concerns synthesis of new derivatives of already existing antiviral drugs; chemical synthesis of such compounds is aimed at creating a new, more effective drug. Another trend in work on new antiviral drugs is the search for natural compounds, mainly of plant origin, in order to obtain potential chemotherapeutic agents. An interesting object of synthesis is formazans -- a class of organic substances with various biological activities.Biological and industrial application of formazans begins with their use as analytical reagents and dyes, and ends, primarily interesting for us, with their usage in pharmacology. They found wide practical usage as dyes, indicators of redox reactions, etc. In medicine, formazans are used due to their antioxidant, antiviral, antimicrobial, analgesic, anthelmintic and other properties. Many formazans are used in medicine as indicators of cancer cells, drugs against tuberculosis, influenza, and fungal diseases. Important advantage in of formazans synthesis is fairly easy and cheap methods of their production, available starting materials and speed of synthesis processes. In addition, an interesting direction in search for effective substances is the synthesis of formazans with luminescent properties, which significantly expand areas of their application. In our case, such organic luminophores are formazanonaphthalimides and formazanoacenaphthenquinones, which are close to them in structure.