Bidirectionally regulated synthetic ferrocene-based aminal-linked porous organic polymer artificial enzyme towards photothermal-amplified synergistic antibacterial and wound healing therapy

Abstract

Development of hetero-atom rich porous organic polymers (POPs) in facile and easy accessible methods are of significant importance to broad application potentials and enrich diversity of such materials. Here, a bidirectional adjustment strategy, starting with amino and aldehyde monomers, concurrently, was used for the rational preparation of N-rich aminal-linked POPs with customized structure and function. Five novel ferrocene-based aminal-linked POPs, were facilely fabricated via the one-pot catalyst-free Schiff base polycondensation between the 1,1′-Ferrocene dicarboxaldehyde and different types of triazine-bearing monomers with diverse geometrical features and functions (Porphyrin, cationic viologen, Ferrocene, 1,4,7,10-tetraazacyclododecane, and benzyl). The concurrent introduction of Ferrocene (redox-active) and triazine-Porphyrin (photoactive) endowed remarkable mimicking peroxidase-like activity and excellent photothermal and photodynamic activity with Fc-TDPP, which could be used as a broad spectrum fungicide, exerting photothermal enhanced photodynamic and enzyme antibacterial therapy. Notably, in vitro and in vivo experiments confirmed Fc-TDPP could not only kill S. aureus and E. coli quickly and efficiently, but also significantly accelerate the repairing of open wounds with S. aureus-infection. The as-proposed strategy are available for the low-cost constructing N-rich POPs with specific structure and functions targeted for wide potential applications in various fields.