Abstract
AbstractFive Ru(II)‐NC complexes were tested as catalysts for α‐alkylation of unactivated amides using alcohols as alkylating agents, and complex {(C5H4N)‐(C6H4)}RuCl(CO)(PPh3)2 (1) showed the highest activity. With 0.5 mol% catalyst loading, a series of α‐alkylated amides were isolated at 80 °C within 6 hours. Furthermore, under similar conditions, complex 1 was also active for α‐alkylation of unactivated esters with alcohols, and the reaction time was shortened to 1.5 hours. The catalytic performance of 1 is comparable to the best reported catalyst.
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