Abstract
We have studied the effects of bicuculline applied in microgram quantities to the precruciate gyrus (motor cortex) of cat upon visually evoked and spontaneous single-unit and slow-wave activity. The bicuculline produced an increase in both the visually evoked and the spontaneous unit activity. A surface negative component of the slow-wave response was markedly enhanced by the bicuculline. This component was associated with an intense suppression of spontaneous single-unit activity. Therefore, we have found that bicuculline has a convulsant effect upon single-unit activity as previously reported by others. However, we also found that bicuculline potentiates a process which appears associated with an enhancement of inhibition.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Electroencephalography and Clinical Neurophysiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
