Abstract
It will be interesting and yet challenging to develop a near-infrared (NIR) laser trigger phototheranostics agent for multimodal imaging guided synergistic phototherapy. In addition, the mechanisms of phototheranostics agent or in combination with NIR for tumor therapy remain unclear. Herein, we fabricate porous Co3O4 nanoplates (pCo3O4 NPs) using a hydrothermal process followed by a calcination treatment. We demonstrate that pCo3O4 NPs are a promising phototheranostics agent for multimodal imaging (photoacoustic/magnetic resonance imaging) and a NIR laser triggered photothermal therapy (PTT) and photodynamic therapy (PDT) of tumors without apparent side effects. Moreover, RNA sequencing (RNA-seq) analysis highlights that pCo3O4 NPs can suppress tumor metastasis via inhibiting epithelial-mesenchymal transition (EMT) pathway. In addition, pCo3O4 NPs could kill tumor cells via inducing DNA damage after NIR irradiation. In summary, the data reveal that pCo3O4 NPs + NIR could effectively suppress tumorigenesis, and further highlight their potential as a nanomaterial-based multimodal imaging contrast agent and precise DNA damage-mediated tumor synergetic phototherapy, providing new insights to fully understand and use phototheranostics agent in the future.
Published Version
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