Bicatalytic Multistep Reactions En Route to the One‐Pot Total Synthesis of Complex Molecules: Easy Access to Chromene and 1,2‐Dihydroquinoline Derivatives from Simple Substrates

Abstract

AbstractBy combining nanocatalysis with base catalysis, a novel one‐pot multistep process was found for the synthesis of substituted heterocycles of biological relevance from simple substrates. The process is based on the initial Au/O2 oxidation of allylic alcohols, which is followed by base‐catalyzed tandem hetero‐Michael/aldolization/crotonization with ortho‐hydroxy‐ or ortho‐aminobenzaldehydes. The flexibility of the reaction even allowed the benzaldehyde partner to be prepared in situ in an example of a one‐pot/five‐step process.